N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2093152-84-0

Molecular Weight: 1652.95

Formula: C78H137N7O30

Chemical Name: cyclooct-4-en-1-yl N-{14-[(2-{2-[2-(2-{N-[2-(2-{2-[2-(1-{[(cyclooct-4-en-1-yloxy)carbonyl]amino}-3,6,9,12-tetraoxapentadecan-15-amido)ethoxy]ethoxy}ethoxy)ethyl]-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12,15,18-hexaoxahenicosan-21-amido}ethoxy)ethoxy]ethoxy}ethyl)carbamoyl]-3,6,9,12-tetraoxatetradecan-1-yl}carbamate

Smiles: O=C(CCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)N(CCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCNC(=O)OC1CCC=CCCC1)CCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCNC(=O)OC1CCC=CCCC1 |c:71,112|

InChiKey: LXEACWVJIHRBDM-LEWNYYKSSA-N

InChi: InChI=1S/C78H137N7O30/c86-71(17-26-85-75(90)15-16-76(85)91)79-21-32-97-44-54-109-64-66-113-68-67-112-65-61-106-51-41-96-31-20-74(89)84(27-37-102-47-57-107-52-42-98-33-22-80-72(87)18-29-94-39-49-104-59-62-110-55-45-100-35-24-82-77(92)114-69-11-7-3-1-4-8-12-69)28-38-103-48-58-108-53-43-99-34-23-81-73(88)19-30-95-40-50-105-60-63-111-56-46-101-36-25-83-78(93)115-70-13-9-5-2-6-10-14-70/h1-3,5,15-16,69-70H,4,6-14,17-68H2,(H,79,86)(H,80,87)(H,81,88)(H,82,92)(H,83,93)/b3-1-,5-2-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.